| Blue Pallet Town (Bulbasaur line) | Pallet Town | 1 | 5 |
| Blue Pallet Town (Charmander line) | Pallet Town | 1 | 5 |
| Blue Pallet Town (Squirtle line) | Pallet Town | 1 | 5 |
| Blue Route 22 Optional (Bulbasaur line) | Route 22 | 3 | 8 |
| Blue Route 22 Optional (Charmander line) | Route 22 | 3 | 8 |
| Blue Route 22 Optional (Squirtle line) | Route 22 | 3 | 8 |
| Gym Leader Brock | Pewter City Gym | 5 | 15 |
| Leaf Mt. Moon (Ivysaur line) | Mt. Moon | 4 | 17 |
| Leaf Mt. Moon (Charmeleon line) | Mt. Moon | 4 | 17 |
| Leaf Mt. Moon (Wartortle line) | Mt. Moon | 4 | 17 |
| Red Mt. Moon (Ivysaur line) | Mt. Moon | 4 | 17 |
| Red Mt. Moon (Charmeleon line) | Mt. Moon | 4 | 17 |
| Red Mt. Moon (Wartortle line) | Mt. Moon | 4 | 17 |
| Team Rocket Jessie & James (Mt. Moon) | Mt. Moon | 3 | 19 |
| Blue Nugget Bridge (Ivysaur line) | Nugget Bridge | 4 | 20 |
| Blue Nugget Bridge (Charmeleon line) | Nugget Bridge | 4 | 20 |
| Blue Nugget Bridge (Wartortle line) | Nugget Bridge | 4 | 20 |
| Rocket Admin Danny (Cerulean City) | Cerulean City | 4 | 22 |
| Gym Leader Misty (Perma Rain) | Cerulean City Gym | 5 | 23 |
| Blue S.S. Anne (Ivysaur line) | S.S. Anne | 5 | 25 |
| Blue S.S. Anne (Charmeleon line) | S.S. Anne | 5 | 25 |
| Blue S.S. Anne (Wartortle line) | S.S. Anne | 5 | 25 |
| Gym Leader Surge | Vermilion City Gym | 6 | 27 |
| Leaf Rock Tunnel (Ivysaur line) | Rock Tunnel | 5 | 28 |
| Leaf Rock Tunnel (Charmeleon line) | Rock Tunnel | 5 | 28 |
| Leaf Rock Tunnel (Wartortle line) | Rock Tunnel | 5 | 28 |
| Red Rock Tunnel (Ivysaur line) | Rock Tunnel | 5 | 28 |
| Red Rock Tunnel (Charmeleon line) | Rock Tunnel | 5 | 28 |
| Red Rock Tunnel (Wartortle line) | Rock Tunnel | 5 | 28 |
| Rocket Admin Sierra (Rocket Hideout) | Rocket Hideout | 5 | 30 |
| Rocket Boss Giovanni (Rocket Hideout) | Rocket Hideout | 5 | 32 |
| Gym Leader Erika (Perma Rain) | Celadon City Gym | 6 | 34 |
| Blue Pokémon Tower (Ivysaur line) (Pre Erika) | Pokémon Tower | 6 | 30 |
| Blue Pokémon Tower (Charmeleon line) (Pre Erika) | Pokémon Tower | 6 | 30 |
| Blue Pokémon Tower (Wartortle line) (Pre Erika) | Pokémon Tower | 6 | 30 |
| Blue Pokémon Tower (Venusaur line) (Post Erika) | Pokémon Tower | 6 | 34 |
| Blue Pokémon Tower (Charizard line) (Post Erika) | Pokémon Tower | 6 | 34 |
| Blue Pokémon Tower (Blastoise line) (Post Erika) | Pokémon Tower | 6 | 34 |
| Rocket Admin Cliff (Pokémon Tower) | Pokémon Tower | 5 | 36 |
| Gym Leader Koga (fifth or sixth gym) | Fuchsia City Gym | 6 | 43 |
| Blue & Leaf Silph Co. (Venusaur line) (Double Battle) | Silph Co. | 5 | 39 |
| Blue & Leaf Silph Co. (Charizard line) (Double Battle) | Silph Co. | 5 | 39 |
| Blue & Leaf Silph Co. (Blastoise line) (Double Battle) | Silph Co. | 5 | 39 |
| Blue & Red Silph Co. (Venusaur line) (Double Battle) | Silph Co. | 5 | 39 |
| Blue & Red Silph Co. (Charizard line) (Double Battle) | Silph Co. | 5 | 39 |
| Blue & Red Silph Co. (Blastoise line) (Double Battle) | Silph Co. | 5 | 39 |
| Rocket Admin Arlo (Silph Co.) | Silph Co. | 5 | 40 |
| Rocket Boss Giovanni (Silph Co.) | Silph Co. | 6 | 41 |
| Gym Leader Sabrina (fifth gym) (Double Battle) | Saffron City Gym | 6 | 43 |
| Gym Leader Sabrina (sixth or seventh gym) (Double Battle) | Saffron City Gym | 6 | 47 |
| Rocket Admin Ivan (Pokemon Mansion) | Pokémon Mansion | 6 | 45 |
| Gym Leader Blaine (sixth or seventh gym) (Double Battle) | Cinnabar Island Gym | 6 | 47 |
| Gym Leader Giovanni | Viridian City Gym | 6 | 51 |
| Leaf Route 22 (Venusaur line) | Route 22 | 6 | 52 |
| Leaf Route 22 (Charizard line) | Route 22 | 6 | 52 |
| Leaf Route 22 (Blastoise line) | Route 22 | 6 | 52 |
| Red Route 22 (Venusaur line) | Route 22 | 6 | 52 |
| Red Route 22 (Charizard line) | Route 22 | 6 | 52 |
| Red Route 22 (Blastoise line) | Route 22 | 6 | 52 |
| Developer SMBZ (Route 23) (Double Battle) | Route 23 | 6 | 54 |
| Elite Four Lorelei | Indigo Plateau | 6 | 57 |
| Elite Four Bruno | Indigo Plateau | 6 | 58 |
| Elite Four Agatha | Indigo Plateau | 6 | 59 |
| Elite Four Lance | Indigo Plateau | 6 | 60 |
| Champion Blue (Venusaur line) | Indigo Plateau | 6 | 63 |
| Champion Blue (Charizard line) | Indigo Plateau | 6 | 63 |
| Champion Blue (Blastoise line) | Indigo Plateau | 6 | 63 |
| Trainer Gold (Four Island) | Four Island | 6 | 60 |
| Rocket Admin Ariana (Rocket Warehouse) | Rocket Warehouse | 6 | 61 |
| Rocket Admin Archer (Rocket Warehouse) | Rocket Warehouse | 6 | 62 |
| Trainer Silver (Rocket Warehouse) | Rocket Warehouse | 6 | 63 |
| Falkner (Canyon Entrance) | Canyon Entrance | 6 | 61 |
| Bugsy (Canyon Entrance) | Canyon Entrance | 6 | 62 |
| Whitney (Canyon Entrance) | Canyon Entrance | 6 | 63 |
| Morty (Canyon Entrance) | Canyon Entrance | 6 | 64 |
| Chuck (Sevault Canyon) | Sevault Canyon | 6 | 65 |
| Jasmine (Sevault Canyon) | Sevault Canyon | 6 | 66 |
| Pryce (Sevault Canyon) | Sevault Canyon | 6 | 67 |
| Clair (Sevault Canyon) | Sevault Canyon | 6 | 68 |
| Developer BPark (Sevault Canyon) | Sevault Canyon | 6 | 69 |
| Trainer Kris (Monean Chamber) | Monean Chamber | 6 | 70 |
| Champion Steven (Five Island) | Five Island | 6 | 70 |
| Developer SMBZ (Trainer Tower) (Double Battle) | Trainer Tower | 6 | 70 |
| Elite Four Lorelei (Rematch) | Indigo Plateau | 6 | 75 |
| Elite Four Bruno (Rematch) | Indigo Plateau | 6 | 76 |
| Elite Four Agatha (Rematch) | Indigo Plateau | 6 | 77 |
| Elite Four Lance (Rematch) | Indigo Plateau | 6 | 78 |
| Champion Blue (Venusaur line) (Rematch) | Indigo Plateau | 6 | 81 |
| Champion Blue (Charizard line) (Rematch) | Indigo Plateau | 6 | 81 |
| Champion Blue (Blastoise line) (Rematch) | Indigo Plateau | 6 | 81 |
| Professor Oak (Cerulean Cave) | Cerulean Cave | 6 | 85 |
| Pooper Derek (Crystaleye Cavern) | Crystaleye Cavern | 6 | 90 |
| Final Boss Dom (Seven Island) | Seven Island | 6 | 100 |